2026
29. Gierke, T., Liu, P., Lu, Y., Tang, S. (2026) Membrane fusions during mammalian fertilization. In: Weiler J, Sieler M, Dittmar T (eds) Springer Nature: Cell Fusion, Adv Exp Med Biol, 1509:87-106. PMID: 42168739. [PDF]
28. Liu, P., Castelino, R.E., Gierke, T.R., Wood, A.J., Lu, Y., Tang, S. (2026) Structure and inhibition of the sperm TMEM95-FIMP complex in mammalian fertilization. bioRxiv 2026.05.14.724122. PMCID: PMC13192804. PMID: 42182310. [PDF] [Github]
27. Wood, A.J., Liu, P., Tang, S. (2026) A molecular lattice reinforces the sperm head-tail junction. Proc Natl Acad Sci U S A 123(20):e2608469123. PMCID: PMC13187801. PMID: 42114004. [PDF]
26. Li, Y., Zheng, W., Leem, J., Wu, C., Tang, S., Mogessie, B., Xiong, Y. (2026) The cytoplasmic lattice in mammalian eggs sequesters ubiquitination machinery and tubulin in reserve. bioRxiv 2026.03.30.715190. PMCID: PMC13060343. PMID: 41959504. [PDF]
25. Chang, H., Gierke, T.R., Tang, S., Lu, Y. (2026) Molecular interplay between sperm and egg: a narrative review. Hum Reprod Update. Online ahead of print. PMID: 41884958. [PDF]
24. Shi, Y., Kim, Y., Liu, P., Wang, J., Tang, S., Batista, V.S. (2026) Computational Evolution of Anti–PD-1 Antibodies Induces Structural Refolding for High-Affinity Interactions. Biochemistry. 65(5):517-520. PMID: 41671420. [PDF]
2025
23. Filsinger Interrante, M.V., Tang, S., Kim, S., Shanker, V.R., Hie, B.L., Bruun, T.U.J., Wu, W., Pak, J.E., Fernandez, D., Kim, P.S. (2025) Utilizing Machine Learning to Improve Neutralization Potency of an HIV-1 Antibody Targeting the gp41 N-Heptad Repeat. ACS Chem Biol. 20(7):1470-1480. PMCID: PMC12281478. PMID: 40540236. [PDF]
22. Lu, Y., Ikawa, M., Tang, S. (2025) Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13. Proc Natl Acad Sci U S A 122(10):e2425952122. PMCID: PMC11912406. PMID: 40042902. [PDF]
2024
21. Xu, D., Carter, J.J., Li, C., Utz, A., Weidenbacher, P.A., Tang, S., Sanyal, M., Pulendran, B., Barns, C.O., Kim, P.S. (2024) Vaccine design via antigen reorientation. Nat Chem Biol. 20(8):1012-1021. PMCID: PMC11247139. PMID: 38225471. [PDF]
20. Hie, B.L., Shanker, V.R., Xu, D., Bruun, T.H.J., Weidenbacher, P.A., Tang, S., Wu, W., Pak, J.E., Kim, P.S. (2024) Efficient evolution of human antibodies from general protein language models. Nat. Biotechnol. 42(2):275-283. PMCID: PMC10869273. PMID: 37095349. [PDF]
2023
19. Skinner, W.M., Petersen, N.T., Unger, B., Tang, S., Tabarsi, E., Lamm, J., Jalalian, L., Smith, J., Bertholet, A.M., Xu, K., Kirichok, Y., Lishko, P.V. (2023) Mitochondrial uncouplers impair human sperm motility without altering ATP content. Biol Reprod. 109(2):192-203. PMCID: PMC10427809. PMID: 37294625. [PDF]
18. Abhiraman, G.C., Bruun, T.U.J., Caveney, N.A., Su, L.L., Saxton, R.A., Yin, Q., Tang, S., Davis, M.M., Jude, K.M., Garcia, K.C. (2023) A structural blueprint for interleukin-21 signal modulation. Cell Rep 42(6):112657. PMCID: PMC10320830. PMID: 37339051. [PDF]
17. Weidenbacher, P.A., Sanyal, M., Friedland, N., Tang, S., Arunachalam, P.S., Hu, M., Kumru, O.S., Morris, M.K., Fontenot, J., Shirreff, L., Do, J., Cheng, Y., Vasudevan, G., Feinberg, M.B., Villinger, F.J., Hanson, C., Joshi, S.B., Volkin, D.B., Pulendran, B., Kim, P.S. (2023) A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates. Nat. Commun. 14(1):2149. PMCID: PMC10110616. PMID: 37069151. [PDF]
16. Bruun, T.U.J., Tang, S., Erwin, G.S., Deis, L.N., Fernandez, D., Kim, P.S. (2023) Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies. J Biol Chem 299(4):103062. PMCID: PMC10064241. PMID: 36841484. [PDF]
15. Lu, Y., Shimada, K., Tang, S., Zhang, J., Ogawa, Y., Noda, T., Shibuya, H., Ikawa, M. (2023) 1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm–egg fusion. Proc Natl Acad Sci U S A 120 (8) e2207263120. PMCID: PMC9974436. PMID: 36787362. [PDF]
14. Weidenbacher, P.A., Musunuri, S., Powel, A.E., Tang, S., Do, J., Sanyal, M., Kim, P.S. (2023) Simplified Purification of Glycoprotein-modified Ferritin Nanoparticles for Vaccine Development. Biochemistry 62(2): 292-299. PMCID: PMC9850919. PMID: 35960597. [PDF]
2022
13. Tang, S., Lu, Y., Skinner, W.M., Sanyal, M., Lishko, P.V., Ikawa, M., Kim, P.S. (2022) Human sperm TMEM95 binds eggs and facilitates membrane fusion. Proc Natl Acad Sci U S A 119 (40) e2207805119. PMCID: PMC9546558. PMID: 36161911. [PDF]
2021
12. Powell, A.E., Zhang, K., Sanyal, M., Tang, S., Weidenbacher, P.A., Li, S., Pham, T.D., Pak, J.E., Chiu, W., and Kim, P.S. (2021) A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice. ACS Cent Sci 7, 183-199. PMCID: PMC7805605. PMID: 33527087. [PDF]
11. Banjade, S., Shah, Y.H., Tang, S., and Emr, S.D. (2021) Design principles of the ESCRT-III Vps24-Vps2 module. eLife 10. PMCID: PMC8143795. PMID: 34028356. [PDF]
2019
10. Tang, S. and Kim, P.S. (2019) A high-affinity human PD-1/PD-L2 complex informs avenues for small-molecule immune checkpoint drug discovery. Proc Natl Acad Sci U S A 116, 24500-24506. PMCID: PMC6900541. PMID: 31727844. [PDF]
9. Banjade, S., Tang, S., and Emr, S.D. (2019) Genetic and Biochemical Analyses of Yeast ESCRT. Methods Mol Biol 1998:105-116. PMID: 31250297. [PDF]
8. Banjade, S., Tang, S., Shah, Y.H., and Emr, S.D. (2019) Electrostatic lateral interactions drive ESCRT-III heteropolymer assembly. eLife 8. PMCID: PMC6663469. PMID: 31246173. [PDF]
2017
7. Jacobson, B.A., Sadiq, A.A., Tang, S., Jay-Dixon, J., Patel, M.R., Drees, J., Sorenson, B.S., Russell, S.J., and Kratzke, R.A. (2017) Cap-dependent translational control of oncolytic measles virus infection in malignant mesothelioma. Oncotarget 8, 63096-63109. PMCID: PMC5609906. PMID: 28968974. [PDF]
2016
6. Tang, S., Buchkovich, N.J., Henne, W.M., Banjade, S., Kim, Y.J., and Emr, S.D. (2016) ESCRT-III activation by parallel action of ESCRT-I/II and ESCRT-0/Bro1 during MVB biogenesis. eLife 5. PMCID: PMC4865371. PMID: 27074665. [PDF]
2015
5. Tang, S., Henne, W.M., Borbat, P.P., Buchkovich, N.J., Freed, J.H., Mao, Y., Fromme, J.C., and Emr, S.D. (2015) Structural basis for activation, assembly and membrane binding of ESCRT-III Snf7 filaments. eLife 4. PMCID: PMC4720517. PMID: 26670543. [PDF]
4. Patel, M.R., Jacobson, B.A., Ji, Y., Drees, J., Tang, S., Xiong, K., Wang, H., Prigge, J.E., Dash, A.S., Kratzke, A.K., et al. (2015) Vesicular stomatitis virus expressing interferon-beta is oncolytic and promotes antitumor immune responses in a syngeneic murine model of non-small cell lung cancer. Oncotarget 6, 33165-33177. PMCID: PMC4741756. PMID: 26431376. [PDF]
3. Jacobson, B.A., Chen, E.Z., Tang, S., Belgum, H.S., McCauley, J.A., Evenson, K.A., Etchison, R.G., Jay-Dixon, J., Patel, M.R., Raza, A., et al. (2015) Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma. Genes Cancer 6, 144-152. PMCID: PMC4426951. PMID: 26000097. [PDF]
2. Meng, S., Tian, T., Han, D., Wang, L., Tang, S., Meng, X., and Li, Z. (2015) Efficient assembly of oligomannosides using the hydrophobically assisted switching phase method. Org Biomol Chem 13, 6711-6722. PMID: 25967589. [PDF]
2013
1. Buchkovich, N.J., Henne, W.M., Tang, S., and Emr, S.D. (2013) Essential N-terminal insertion motif anchors the ESCRT-III filament during MVB vesicle formation. Dev Cell 27, 201-214. PMID: 24139821. [PDF]