MB&B 7200 Macromolecular Structure and Biophysical Analysis (Fall 2026, Fall 2025, Fall 2024)
Fall, Tuesdays and Thursdays, 11:35 am – 12:50 pm, Bass Center 405
This course provides an in-depth analysis of macromolecular structure through the integrated application of structural biology, spectroscopy, and biochemistry. It emphasizes how these complementary approaches collectively advance our understanding of molecular structure and function. Topics include the structural organization of proteins, RNA, and DNA; practical strategies for structural determination; and an introduction to key techniques such as X-ray diffraction, cryo-electron microscopy (cryo-EM), and AI-based structure prediction. Required of MB&B graduate students.
MB&B 7100 Electron Cryo-Microscopy for Protein Structure Determination (Spring 2027, Spring 2026)
Spring, Tuesdays and Thursdays, 10 am – 11:15 am, Bass Center 405
Understanding cellular function requires structural and biochemical studies at an ever-increasing level of complexity. The course is an introduction to the concepts and applications of high-resolution electron cryo-microscopy. This rapidly emerging new technique is the only method that allows biological macromolecules to be studied at all levels of resolution from cellular organization to near atomic detail.
MB&B 6760 Responsible Conduct of Research (Spring 2026)
Spring, Fridays, 3 pm – 4 pm, Sterling Hall of Medicine C103
Designed for students who are beginning to do scientific research. The course seeks to describe some of the basic features of life in contemporary research and some of the personal and professional issues that researchers encounter in their work. Approximately six sessions, run in a seminar/discussion format. Required of and open only to first-year graduate students in BQBS.
MB&B 3000 Principles of Biochemistry I (Fall 2025)
Fall, Tuesdays and Thursdays, 11:35 am – 12:50 pm, Linsly-Chittenden Hall 102
Discussion of the physical, structural, and functional properties of proteins, lipids, and carbohydrates, three major classes of molecules in living organisms. Energy metabolism and hormone signaling as examples of complex biological processes whose underlying mechanisms can be understood by identifying and analyzing the molecules responsible for these phenomena. Required of MB&B majors at Yale College.
MB&B 7300 Methods and Logic in Molecular Biology (Fall 2025)
Fall, Tuesdays and Thursdays, 1:45 pm – 3:45 pm, Bass Center 405
The course examines fundamental concepts in molecular biology through intense critical analysis of the primary literature. The objective is to develop primary literature reading and critical thinking skills. Required of and open only to first-year graduate students in BQBS.
MCDB 3000 Biochemistry (Fall 2024)
Fall, Mondays, Wednesdays, and Fridays, 9:25 am – 10:15 am, Dunham Laboratory 220
An introduction to the biochemistry of animals, plants, and microorganisms, emphasizing the relations of chemical principles and structure to the evolution and regulation of living systems.